Rapid Kinetics of Dehalogenation Promoted by Iodotyrosine Deiodinase from Human Thyroid
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چکیده
منابع مشابه
Rapid Kinetics of Dehalogenation Promoted by Iodotyrosine Deiodinase from Human Thyroid
Reductive dehalogenation such as that catalyzed by iodotyrosine deiodinase (IYD) is highly unusual in aerobic organisms but necessary for iodide salvage from iodotyrosine generated during thyroxine biosynthesis. Equally unusual is the dependence of this process on flavin. Rapid kinetics have now been used to define the basic processes involved in IYD catalysis. Time-dependent quenching of flavi...
متن کاملPurification and characterization of a flavoprotein from bovine thyroid with iodotyrosine deiodinase activity.
A soluble flavoprotein with iodotyrosine deiodinase activity, prepared from steapsin-treated bovine thyroid particulate fractions (mitochondria and microsomes) has been purified to near homogeneity as judged by electrophoretic criteria under native and dissociating conditions. The purification procedure involved ammonium sulfate fractionation of the steapsin-solubilized material followed by chr...
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Title of Document: CATALYTIC FEATURES OF THE IODINE SALVAGING ENZYME IODOTYROSINE DEIODINASE. Patrick Michael McTamney, II Doctor of Philosophy, 2009 Directed By: Professor Steven Rokita Department of Chemistry and Biochemistry The need for iodide in biology is almost exclusively limited to its role in thyroid hormones, yet the recycling of thyroidal iodide is still critical for human health. T...
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Many synthetic chemicals have been identified as environmental contaminants with activity to disrupt normal function of the thyroid hormone system. Thyroid hormones play important roles in growth, development, differentiation, and basal metabolic homeostasis, as well as in brain development in human fetus and children, and thyroid dysfunction can have very serious consequences, including mental...
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Type 2 iodothyronine deiodinase (D2) is a recently cloned selenodeiodinase thought to provide intracellular 3,5,3' triiodothyronine (T3) to a restricted group of tissues. We report here the presence of D2 mRNA in human thyroid at levels 50-150-fold higher than in placenta. Surprisingly, while type 1 deiodinase (D1) is known to be present in human thyroid, D2 has not been evaluated previously. D...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2015
ISSN: 0006-2960,1520-4995
DOI: 10.1021/acs.biochem.5b00410